DNA Methylation AIDS HIV Latency
July 1st, 2009. One of the world\'s most elusive viruses is an expert at maintaining a low profile, laying dormant in CD4+ cells even during highly active antiretroviral treatment (HAART). A team of American and Swedish researchers found that the virus might be using DNA methylation as a cloak. Read more...
Don’t Go Away Mad (Just GOmir)
July 1st, 2009. Figuring out the targets of your favorite miRNA is no simple matter, and if it ranks somewhere between cleaning the bathroom and a trip to the dentist on your list, then you’ll want to check out a new java-based tool called GOmir which makes the miRNA target analysis experience a little less painful. Read more...
Erring on the Side of Calling: Sequencing Mismatches Highlight RNA Editing
July 1st, 2009. To err is enzymatic; to identify errors previously thought to be technical, but are actually biologically relevant, is divine. A Canadian team of researchers recently showed that many of the mismatch, non-conformist sequences that are typically thrown aside during analysis, are central players in another emerging area of RNA regulation. Read more...
HIV’s RISC-y Behavior
July 1st, 2009. Researchers from U Mass Med School in Worchester, and the Burnham Institute for Medical Research in La Jolla, found that HIV mRNA hangs around with RNA-induced silencing complexes (RISCs) and cytoplasmic mRNA-processing-bodies (P bodies) in latently infected cells. Adding in more miR-29a enhances the relationship. Read more...
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